abstract：:Monocarboxylate transporter (MCT1) levels in brains of adult Long-Evans rats on a high-fat (ketogenic) diet were investigated using light and electron microscopic immunocytochemical methods. Rats given the ketogenic diet (91% fat and 9% protein) for up to 6 weeks had increased levels of the monocarboxylate transporter...

journal_title：Neurochemistry international

authors： Leino RL,Gerhart DZ,Duelli R,Enerson BE,Drewes LR

更新日期：2001-05-01 00:00:00

abstract：:E1 mice are an animal model of human epilepsy (idiopathic complex partial seizures). We have previously demonstrated abrupt poly(A)(+) RNA expression in liver from 1-day-old E1 mouse [Mita et al., 1991. Devl. Brain Res. 64, 27-35]. In the present study, we constructed a cDNA library of the poly(A)(+) RNA. By analyzing...

journal_title：Neurochemistry international

authors： Mita T,Kawazu I,Hirano H,Ohmori O,Janjua N,Shibata K

更新日期：2001-04-01 00:00:00

abstract：:The effects of hypoxia on the metabolism of the central nervous system were investigated in rats submitted to a low oxygen atmosphere (8% O(2); 92% N(2)). [1-(13)C]glucose and [2-(13)C]acetate were used as substrates, this latter being preferentially metabolized by glial cells. After 1-h substrate infusion, the incorp...

journal_title：Neurochemistry international

authors： Chateil J,Biran M,Thiaudière E,Canioni P,Merle M

更新日期：2001-04-01 00:00:00

abstract：:The alternative routes of cleavage of the amyloid precursor protein (APP) result in the generation and secretion of both soluble APP and beta-amyloid, the latter being the main component of the amyloid deposits in the brains of individuals with Alzheimer's disease (AD). This study examined the question of whether acet...

journal_title：Neurochemistry international

authors： Pakaski M,Rakonczay Z,Kasa P

更新日期：2001-03-01 00:00:00

abstract：:Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic modulator and also as a neuromodulator at the synaptic level. We will present evidence to suggest that these two different modulatory roles are fulfilled by extracellular adenosine originated from different metabolic sources, and involv...

journal_title：Neurochemistry international

authors： Cunha RA

更新日期：2001-02-01 00:00:00

abstract：:Choline-O-acetyltransferase (ChAT) is the enzyme which catalyses the biosynthesis of the neurotransmitter acetylcholine in cholinergic neurons. Here we show that in mouse cholinergic NS-20Y neuroblastoma cells cultured in the presence of either okadaic acid (serine/threonine phosphatases 1 and 2A inhibitor) or KN-62 (...

journal_title：Neurochemistry international

authors： Pahud G,Bontron S,Eder-Colli L

更新日期：2001-01-01 00:00:00

abstract：:Thyrotropin releasing hormone (TRH) present in several brain areas has been proposed as a neuromodulator. Its administration produces opposite effects to those observed with acute ethanol consumption. Opioid peptides, in contrast, have been proposed to mediate some of the effects of alcohol intoxication. We measured T...

journal_title：Neurochemistry international

authors： de Gortari P,Méndez M,Rodríguez-Keller I,Pérez-Martínez L,Joseph-Bravob P

更新日期：2000-11-01 00:00:00

abstract：:Sodium-dependent transporters regulate extracellular glutamate in the CNS. Recent studies suggest that the activity of several different neurotransmitter transporters can be rapidly regulated by a variety of mechanisms. In the present study, we report that pre-incubation of primary 'astrocyte-poor' neuronal cultures w...

journal_title：Neurochemistry international

authors： Munir M,Correale DM,Robinson MB

更新日期：2000-08-01 00:00:00

abstract：:This study evaluated the effects of a novel, pH-sensitive surfactant, dodecyl 2-(1'-imidazolyl) propionate (DIP), on cationic lipid mediated transfection in primary rat brain neuronal and glial cultures. The cationic lipid complex DOTAP/DOPE (1, 2-dioleoyl-3-trimethylammonium propionate and dioleoyl phosphatidylethano...

journal_title：Neurochemistry international

authors： Wang S,Bui V,Hughes JA,King MA,Meyer EM

更新日期：2000-07-01 00:00:00

abstract：:Glial (GLT-1 and GLAST) and neuronal (EAAC1) high-affinity transporters mediate the sodium dependent glutamate reuptake in mammalian brain. Their dysfunction leads to neuronal damage by allowing glutamate to remain in the synaptic cleft for a longer duration. The purpose of the present study is to understand their con...

journal_title：Neurochemistry international

authors： Raghavendra Rao VL,Rao AM,Dogan A,Bowen KK,Hatcher J,Rothstein JD,Dempsey RJ

更新日期：2000-05-01 00:00:00

abstract：:The relationship between acidosis and the metabolism of glutamine and glutamate was studied in cultured astrocytes. Acidification of the incubation medium was associated with an increased formation of aspartate from glutamate and glutamine. The rise of the intracellular content of aspartate was accompanied by a signif...

journal_title：Neurochemistry international

authors： Yudkoff M,Daikhin Y,Nissim I,Nissim I

更新日期：2000-04-01 00:00:00

abstract：:The expression of 5-hydroxytryptamine-2B (5-HT2B) receptor mRNA has recently been shown in cultured astrocytes. Here the expression of functional 5-HT2B receptors has been studied in cultured astrocytes from rat cerebral cortex, hippocampus, and brain stem. Fluo-3- and fura-2-based microspectrofluorometry was used for...

journal_title：Neurochemistry international

authors： Sandén N,Thorlin T,Blomstrand F,Persson PA,Hansson E

更新日期：2000-04-01 00:00:00

abstract：:The Alzheimer's disease amyloid protein precursor (APP) gene is part of a multi-gene super-family from which sixteen homologous amyloid precursor-like proteins (APLP) and APP species homologues have been isolated and characterised. Comparison of exon structure (including the uncharacterised APL-1 gene), construction o...

journal_title：Neurochemistry international

authors： Coulson EJ,Paliga K,Beyreuther K,Masters CL

更新日期：2000-03-01 00:00:00

abstract：:Rapid eye movement sleep deprivation is associated with an increase in Na-K ATPase activity. In order to understand the possible biochemical mechanism of this increase, the kinetics of Na-K ATPase was studied. Although the enzyme activity increased after the deprivation, the catalytic efficiency of the enzyme remained...

journal_title：Neurochemistry international

authors： Adya HV,Mallick BN

更新日期：2000-03-01 00:00:00

abstract：:Glutamate is an excitotoxin responsible for causing neuronal damage associated with mitochondria dysfunction. We have analyzed the relationship between the mitochondrial respiratory rate, the membrane potential (delta psi) and the activity of mitochondrial complexes in retinal cells in culture, used as neuronal models...

journal_title：Neurochemistry international

authors： Rego AC,Santos MS,Oliveira CR

更新日期：2000-02-01 00:00:00

abstract：:The Xenopus oocyte expression and recording system has allowed a detailed analysis of the physiology and pharmacology of neuronal ion channels including their sensitivity to ethanol. It is important however, to ascertain the effects of a particular drug on the channels inherently expressed by oocytes to ensure that dr...

journal_title：Neurochemistry international

authors： Clayton R,Woodward JJ

更新日期：2000-01-01 00:00:00

abstract：:To investigate the contribution of the dopamine (DA) synthesis to both the calcium-dependent and the carrier-mediated, mechanisms of DA release in the striatum, anaesthetized rats were locally superfused in the striatum with a push pull cannula supplied with an artificial CSF containing tritiated tyrosine. DA, dihydro...

journal_title：Neurochemistry international

authors： Olivier V,Gobert A,Guibert B,Leviel V

更新日期：1999-12-01 00:00:00

abstract：:Selective dopaminergic neurotoxicity induced by 1-methyl-4-phenylpyridine (MPP+) is believed to be due to the transmembrane uptake by the dopamine transporter and subsequent inhibition of mitochondrial complex I and/or production of free radicals. However, little is known about the molecular sequence of intracellular ...

journal_title：Neurochemistry international

authors： Storch A,Ludolph AC,Schwarz J

更新日期：1999-11-01 00:00:00

abstract：:Taurine is found at millimolar concentration in the retina and retinal pigment epithelium. High concentrations of taurine are essential for maintenance of retinal function. Taurine uptake by retina and retinal pigment epithelium was significantly enhanced by physiological concentrations of insulin as well as by high g...

journal_title：Neurochemistry international

authors： Salceda R

更新日期：1999-10-01 00:00:00

abstract：:Intracellular Ca2+ signals produced by the glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA; 5 microM) were measured in the somatic and dendritic regions of cerebellar Purkinje neurons in mature cerebellar control cultures (> or = 20 days in vitro) and cultures chronically treated...

journal_title：Neurochemistry international

authors： Netzeband JG,Trotter C,Caguioa JN,Gruol DL

更新日期：1999-08-01 00:00:00

abstract：:The integrity of hippocampal G-protein mediated signalling following ibotenate induced lesion of the medial septum was examined. The lesion was confined histologically to the septum and induced a 23% reduction in hippocampal choline acetyltransferase (ChAT) activity and G-proteins levels and related enzyme activities ...

journal_title：Neurochemistry international

authors： McLaughlin M,Inglis FM,Ross BM,Breen KC,McCulloch J

更新日期：1999-07-01 00:00:00

abstract：:GABA release and uptake were examined in Genetic Absence Epilepsy Rats from Strasbourg and in non-epileptic control animals, using crude synaptosomes prepared from the cerebral cortex and thalamus. Uptake of [3H]GABA over time was reduced in thalamic synaptosomes from epileptic rats, compared to controls. The affinity...

journal_title：Neurochemistry international

authors： Sutch RJ,Davies CC,Bowery NG

更新日期：1999-05-01 00:00:00

abstract：:Potassium bisperoxo(1,10-phenantroline)oxovanadate (V) [bpV(phen)] is a potent protein tyrocine phosphatase inhibitor which mediates a variety of biological effects. The aim of these studies was to examine the role(s) of mitogen activated protein kinase (MAPK) pathways in PC12 cell proliferation and toxicity by bpV(ph...

journal_title：Neurochemistry international

authors： Cerovac Z,Ban J,Morinville A,Yaccato K,Shaver A,Maysinger D

更新日期：1999-04-01 00:00:00

abstract：:There is experimental evidence from radioligand binding experiments for the existence of strong antagonistic interactions between different subtypes of adenosine and dopamine receptors in the striatum, mainly between adenosine A1 and dopamine D1 and between adenosine A2A and dopamine D2 receptors. These interactions s...

journal_title：Neurochemistry international

authors： Lillrank SM,Lipska BK,Weinberger DR,Fredholm BB,Fuxe K,Ferré S

更新日期：1999-03-01 00:00:00

abstract：:The activities of the enzymes glutathione reductase (GRD), glutathione peroxidase (GPX), and glutathione S-transferase (GST) were studied in several rat brain areas following the aspirative transection of the septohippocampal pathway (fimbria fornix) and the administration of nerve growth factor (NGF) or cytochrome c....

journal_title：Neurochemistry international

authors： Cruz-Aguado R,Francis-Turner L,Díaz-Suárez CM,Bergado J

更新日期：1999-02-01 00:00:00

abstract：:Dyskinesia is frequently seen in neurological disorders affecting the basal ganglia. Iminodipropionitrile (IDPN) produces a somewhat similar motor syndrome in rodents, one that is a possible model for dyskinesia. Because in previous studies the compound (N-[2-hydroxy-3-(1-piperidinyl) propoxy]-3 pyridine-carboximidoyl...

journal_title：Neurochemistry international

authors： Tóth E,Gerevich Z,Dóda M,Lajtha A

更新日期：1998-12-01 00:00:00

abstract：:Using native plasma membrane vesicle suspensions from the rat cerebral cortex under conditions designed to alter intravesicular [Ca2+], we found that Ca2+ induced 47 +/- 5% more influx of [3H]GABA, [3H]D-aspartate and [3H]glycine at 37 degrees C with half-times 1.7 +/- 0.5, 1.3 +/- 0.4 and 1.3 +/- 0.4 min, respectivel...

journal_title：Neurochemistry international

authors： Kovács I,Szárics E,Nyitrai G,Blandl T,Kardos J

更新日期：1998-11-01 00:00:00

abstract：:The mechanism of action of lithium (Li) alone or with pilocarpine (Pilo), focusing on muscarinic and dopaminergic systems and also on phosphoinositide metabolism was studied. Li (3 mEq/kg) administered to rats once (1 d) or daily for 7 days (7 d), 24 h before Pilo (15 mg/kg), exacerbated cholinergic signs, leading to ...

journal_title：Neurochemistry international

authors： Marinho MM,de Sousa FC,de Bruin VM,Vale MR,Viana GS

更新日期：1998-10-01 00:00:00

abstract：:Serotonin (5-HT) is a prime candidate for studies of the interaction between the nervous and immune systems, since it is both an important neurotransmitter and released at high concentrations at sites of inflammation. Serotonergic neurotransmission is regulated by the 5-HT transporter (5-HTT), which determines the mag...

journal_title：Neurochemistry international

authors： Mössner R,Heils A,Stöber G,Okladnova O,Daniel S,Lesch KP

更新日期：1998-09-01 00:00:00

abstract：:The neurotoxic beta-amyloid (Abeta) peptide fragment Abeta(25-35) has been suggested to exert its deleterious effects on cells via production of hydrogen peroxide. In human platelets and in the presence of DMSO to prevent production of hydroxyl radicals from hydrogen peroxide, both Abeta(25-35) and hydrogen peroxide w...

journal_title：Neurochemistry international

authors： Fowler CJ,Ando Y,Tiger G

更新日期：1998-08-01 00:00:00

abstract：:A significant loss of dopamine was found in rat striatal slices incubated with 1-methyl-4-phenylpyridinium ion (MPP+) at a concentration of 2 microM or higher. The addition of 7-nitroindazole, a specific inhibitor of neuronal nitric oxide synthase (nNOS), prevented this effect on dopamine when the concentration of MPP...

journal_title：Neurochemistry international

authors： Cutillas B,Espejo M,Ambrosio S

更新日期：1998-07-01 00:00:00

abstract：:Nucleotides can be released as signaling substances in the nervous system from both neural and glial cells. Their function is terminated by ecto-nucleotidases and sequential extracellular metabolism to the nucleoside. Recently considerable progress has been made in unraveling the molecular structure of an ecto-ATPase ...

journal_title：Neurochemistry international

authors： Zimmermann H,Braun N,Kegel B,Heine P

更新日期：1998-05-01 00:00:00

abstract：:AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) excitotoxicity was examined in cultured neocortical neurons using the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to measure cell viability. Neurons were exposed to AMPA at different culture periods during development o...

journal_title：Neurochemistry international

authors： Jensen JB,Schousboe A,Pickering DS

更新日期：1998-05-01 00:00:00

abstract：:Aminoethylcysteine ketimine is a sulfur-containing cyclic compound produced by the enzymatic alpha-deamination of the parent aminoethylcysteine that has been detected in bovine brain and cerebellum. Aminoethylcysteine ketimine is known to dimerize spontaneously and easily lose one carboxyl group. This decarboxylated c...

journal_title：Neurochemistry international

authors： Matarese RM,Macone A,Crescentini G,Duprè S,Cavallini D

更新日期：1998-04-01 00:00:00

abstract：:Cyclothiazide has been shown to block desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-preferring receptors and to enhance quisqualate-, AMPA- and kainate-induced neurotoxicity. The pharmacology behind this cyclothiazide-enhanced kainate-induced excitotoxicity was characterized in em...

journal_title：Neurochemistry international

authors： Ohno K,Okada M,Tsutsumi R,Matsumoto N,Yamaguchi T

更新日期：1998-03-01 00:00:00

abstract：:Short-term supplementation of low protein diet (LPD) or high protein diet (HPD) to the aged (18 months old) rats did not change the hypothalamic GABAergic activity and immune response. Long-term supplementation of LPD on the other hand, enhanced hypothalamic GABAergic activity with an immunopotentiation by increasing ...

journal_title：Neurochemistry international

authors： Bandyopadhyay BC,Poddar MK

更新日期：1998-02-01 00:00:00

abstract：:A possible modulatory role of kinases on voltage sensitive Na+ channels of presynaptic brain nerve endings was investigated by testing the effect of several kinase activators and inhibitors on the elevation of [Nai] induced by veratridine in mouse brain synaptosomes loaded with a selective Na+ indicator dye. Veratridi...

journal_title：Neurochemistry international

authors： Sitges M,Peña F,Chiu LM,Guarneros A

更新日期：1998-02-01 00:00:00

abstract：:The venom from the marine snail Conus pennaceus inhibits the binding of [3H]neuropeptide Y to calf brain membranes (Czerwiec et al., 1996a) and, in the present study, also to rat forebrain membranes. These membranes contain about 80% Y1- and 20% Y2-receptors. The inhibition by the venom was concentration-dependent wit...

journal_title：Neurochemistry international

authors： Diallo B,Vanderheyden PM,De Backer JP,Vauquelin G

更新日期：1998-01-01 00:00:00

abstract：:The effect of different dietary fats with varying degrees of unsaturation and essential fatty acid composition, which are commonly consumed in India, on the activity of some important membrane-bound enzymes was assessed in different brain regions of rat. Four groups of male CFY weanling rats were fed nutritionally ade...

journal_title：Neurochemistry international

authors： Srinivasarao P,Narayanareddy K,Vajreswari A,Rupalatha M,Prakash PS,Rao P

更新日期：1997-12-01 00:00:00

abstract：:The phosphorylation of proteins on tyrosine residues, initially believed to be primarily involved in cell growth and differentiation, is now recognized as having a critical role in regulating the function of mature cells. The brain exhibits one of the highest levels of tyrosine kinase activity in the adult animal and ...

journal_title：Neurochemistry international

authors： Gurd JW

更新日期：1997-11-01 00:00:00